全身亚低温对新生儿缺氧缺血性脑病的近期和远期治疗效果

Analysis of short-term and long-term effects of systemic hypothermia on neonatal hypoxic ischemic encephalopathy

目的:研究分析在新生儿缺氧缺血性脑病的治疗中采用全身亚低温的临床近期和远期治疗效果。方法:选取2015年3月~2017年8月在永州市第四人民医院接受缺氧缺血性脑病治疗的新生儿48例,随机分为研究组和对照组各24例,研究组新生儿在出生后的10~12 h进行全身亚低温治疗,并维持新生儿的肛温在33.5~34.5℃,持续时间为72 h;维持对照组新生儿肛温在36.5~37.5℃,同时给予两组新生儿相同的其余治疗手段。最后采用婴幼儿智能运动发育检测、新生儿神经行为测定等方式对两组新生儿的近期和远期的治疗效果进行对比。结果:两组新生儿在经过不同的治疗方式之后,研究组新生儿的婴幼儿智能运动发育检测、新生儿神经行为测定都明显优于对照组,差异均有统计学意义(P<0.05)。结论:在新生儿缺氧缺血性脑病的治疗中采用全身亚低温有着显著的近期和远期神经保护作用,值得在临床上大力推广。

Objective To study and analyze the short-term and long-term therapeutic effects of systemic hypothermia in the treatment of neonatal hypoxic ischemic encephalopathy.Method 48 newborns treated with hypoxic ischemic encephalopathy in our hospital from March 2015 to August 2017 were randomly divided into a study group and a control group,with 24 neonates in each group.The study group was treated with mild hypothermia for the newborn,and the study group was given full body mild hypothermia within 10~12 hours after birth.The treatment,and maintenance of the neonatal Anal temperature from 33.5 to 34.5 C,duration of 72 hours,maintaining the control group's anus temperature at 36.5 to 37.5 C,and giving the same treatment for the two groups of newborns at the same time.Finally,the children's intelligent motor development test and the neonatal divine behavior measurement were used in two groups of newborns.The effect of recent and long term treatment was compared.Results After different treatment of two groups of newborns,the detection of infant's intelligent motor development and neonatal neurobehavioral test of the study group were obviously better than those of the control group(P<0.05).Conclusion The use of systemic hypothermia in the treatment of hypoxic-ischemic encephalopathy in newborns has significant short-term and long-term neuroprotective effect,which is worthy of being popularized in clinical.