醒神开郁针法对脑卒中后抑郁患者临床疗效、SAS及HAMD量表评分、5-HT水平影响研究

Clinical efficacy,SAS and HAMD scale scores and 5-HT level of patients with post-stroke depression treated by awakening The Mind and opening the qi needle

目的探究醒神开郁针法对脑卒中后抑郁患者临床疗效、SAS及HAMD量表评分、5-HT水平影响。方法将我院纳入的93例脑卒中后抑郁以随机数字表法分为两组,予以对照组患者(46例)常规西药治疗,观察组患者(47例)在对照组治疗基础上联合醒神开郁针法治疗,比较两组患者治疗效果、治疗前后抑郁自评量表(SDS)及汉密尔顿抑郁量表(HAMD)评分变化、5-羟色胺(5-HT)水平变化、神经功能缺损量表(NHISS)评分及日常生活活动能力(ADL)、简易智力状态检查量表(MMSE)评分变化、血清白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平变化、不良反应情况。结果观察组患者治疗总有效率(95.74%)高于对照组(82.61%)(P<0.05),治疗前,两组患者SDS、HAMD、5-HT、NHISS、ADL、MMSE、IL-6、IL-8、TNF-α等指标比较(P>0.05);治疗后各组患者SDS、HAMD、5-HT、NHISS、ADL、MMSE、IL-6、IL-8、TNF-α等指标均改善。观察组患者治疗后SDS、HAMD、5-HT、NHISS、ADL、MMSE、IL-6、IL-8、TNF-α等指标均优于对照组(P<0.05);观察组患者不良反应率(2.13%)低于对照组(15.22%)(P<0.05)。结论醒神开郁针法治疗脑卒中后抑郁临床疗效显著,患者抑郁症状改善,恢复良好,同时还可降低患者服药副反应,安全可靠,值得应用。

Objective To explore the clinical effect,SAS and HAMD scale score and 5-HT level of patients with post-stroke depression treated by awakening the mind and opening the qi needle.Methods A total of 93 patients with poststroke depression were included in the study,all of whom were admitted to our hospital from September 2018 to October 2020.Patients were divided into the control group and the observation group by random number table method.Patients in the control group(46 cases)were given conventional western medicine treatment.We compared between two groups of patients before and after treatment,treatment of depression self-rating scale(SDS)and Hamilton depression scale(HAMD)score changes,serotonin(5-HT)level change and neural function defect scale(NHISS)score and active ability of daily life(ADL)scale,simple mental state examination(MMSE)score changes,serum interleukin 6(IL-6),interleukin 8(IL-8),tumor necrosis factor alpha(TNF alpha)level changes,adverse reaction conditions.Results The total effective rate(95.74%)in the observation group was higher than that in the control group(82.61%)(P<0.05).Before the treatment,two groups of patients with SDS,HAMD,5-HT,NHISS,ADL,MMSE,IL-6,IL-8 and TNF alpha index comparison(P>0.05),groups of patients after treatment,HAMD,SDS 5-HT,NHISS,ADL,MMSE,IL-6,IL-8,TNF alpha indexes are improved,such as observation group after treatment in patients with SDS,HAMD,5-HT,NHISS,ADL,MMSE,IL-6,IL-8 and TNF alpha indicators are superior to control group(P<0.05).The adverse reaction rate in the observation group(2.13%)was lower than that in the control group(15.22%)(P<0.05).Conclusion The method of“awakening the mind and opening the depression”has a significant clinical effect on post-stroke depression.The patients’depressive symptoms are improved and the recovery is good.Meanwhile,it can also reduce the side effects of medication in patients.