摘要
6/7-Seco rearranged spiro-indolone alkaloids,meloyunines A(1)and B(2)and a monoterpenoid quinoline alkaloid meloyunine C(3)together with its possible intermediate 14,15-dehydromelohenine B(4),and their precursorΔ14-vincamenine(5)were isolated from Melodinus yunnanensis.All structures were elucidated based on NMR,FTIR,UV,and MS spectroscopic data.The isolation of monoterpenoid indole,quinoline,and its immediate from the same plant chemically supported the biosynthesis of quinoline from indole.Compound 2 was cytotoxic against several human cancer cell lines.
基金
This work was supported in part by the National Natural Science Foundation of China(2107298)
the 973 Program of Ministry of Science and Technology of P.R.China(2009CB522300)
Chinese Academy of Sciences(KSCX2-EW-R-15 and XiBuZhiGuang Project).
