摘要
Crataeva tapia bark lectin was evaluated for its antitumor activity against sarcoma 180 in Swiss albino mice.The anti-inflammatory and analgesic properties were investigated in models of inflammation and nociception.The anti-inflammatory assay was induced by carrageenan induced peritonitis and the analgesic activity was induced by acetic acid-induced writhing response.The lectin presents low toxicity with a LD50 of 2,500 mg/kg body weight and significant antitumor activity causing inhibition of tumor growth.The lectin also promoted significant reduction(35.4%)in the number of neutrophil migration induced by carrageenan.Concerning its analgesic property,the lectin inhibits abdominal contractions induced by acetic acid.The current results revealed a lectin with significant antitumoral,anti-inflammatory and antinociceptive activities.Further investigations to unveil the exact mechanisms are needed.
基金
This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)
The authors also wish to thank Ronaldo Celerino da Silva and Sílvia Rafaelli Ramos for their valuable technical assistance.
