摘要
Three new ent-kauranoids,isorosthornins A-C(1-3),and a new natural product,dihydroponicidin(4),together with five known ones were isolated from the aerial parts of Isodon rosthornii.The structures were determined by means of extensive spectroscopic analysis.All diterpenoids isolated were evaluated for their cytotoxicity against HL-60,SMMC-7721,A-549,MCF-7,and SW480 cell lines,and compounds 5 and 7 showed significant inhibitory effects on all cell lines.
基金
This work was supported financially by the NSFC-Joint Foundation of Yunnan Province(No.U0832602 to H.D.Sun)
the Major State Basic Research Development Program of China(No.2009CB522300 and 2009CB940900)
the Science and Technology Program of Yunnan Province(No.2008IF010 and 2008CD162)
the NSFC(No.81172939 to J.X.Pu)
the Major Direction Projection Foundation of CAS Intellectual Innovation Project(No.2010KIBA05 to J.X.Pu).
