摘要
The first total synthesis of(-)-huperzine W(1)has been achieved.Key element of the synthesis is a highly convergent assemblage for the two rings system of target molecule utilizing an efficient Suzuki-Miyaura coupling reaction between chiral iodide 2 and 2-allylpyrrolidinone 4.Evaluation of the AchE inhibition of synthetic huperzine W was also carried out.
基金
the National Natural Science of China(No.20802084,21072200)
Programs of“One Hundred Talented People”and“Western Light”Joint Scholar of Chinese Academy of Sciences for financial support.
