摘要
In a previous publication in Cellular and Molecular Immunology,Zhao et al.1 showed data from patients with treatment-naïve systemic lupus erythematosus(SLE),demonstrating the clinical significance and possible mechanisms of the aberrant expression of the chemokine receptor CXCR4 on lupus B cells.In this commentary,we will discuss the roles of CXCL12-CXCR4 and CXCL13-CXCR5 pairs and related signaling pathways in guiding dynamic germinal center(GC)reactions and B cell selection and describe how their dysregulation may contribute to the pathogenesis of SLE.
基金
supported by grants from the National Natural Science Foundation of China(81788101,81630044,81601432,81771763,91542000)
the Chinese Academy of Medical Science Innovation Fund for Medical Sciences(CIFMS2016-I2M-1-003,2017-I2M-1-008,2017-I2M-3-011,2016-I2M-1-008)
the Natural Science Foundation of Beijing,China(7182129).
