血清肿瘤标志物与晚期乳腺癌伴肝转移的患者化疗疗效评估的关系

Relationship between serum tumor markers and chemotherapy efficacy evaluation in advanced breast cancer patients with liver metastasis

目的探讨血清肿瘤标志物CEA、CA125、CA15-3、AFP、CA19-9化疗前后变化程度与晚期乳腺癌伴肝转移患者化疗疗效评估的关系。方法筛选2015年9月-2019年10月在本院进行诊治的晚期乳腺癌女性患者,根据化疗方案的更替,确定有效实验数据58例,回顾性分析所有患者化疗前后肿瘤标志物表达水平及影像学特征。通过影像学评估将患者分成缓解组、稳定组和进展组,分析化疗前后肿瘤标志物变化程度与化疗疗效的关系,分析肿瘤标志物与电子计算机断层扫描(CT)对化疗疗效评价的一致性。结果根据实体瘤疗效评价标准进行评价,缓解组13例,稳定组21例,进展组24例,多组间比较发现CEA、CA125、CA15-3变化程度与化疗疗效评估有关(P<0.05)。缓解组与进展组CEA、CA125、CA15-3变化程度与CT化疗疗效评价的一致性较好(Kappa值分别为0.557、0.525、0.656,P<0.05)。结论CEA、CA125、CA15-3变化程度与晚期乳腺癌肝转移患者化疗疗效有关;CEA、CA125、CA15-3变化程度与CT对缓解组及进展组化疗疗效的评价有较好的一致性。

Objective To explore the relationship between the changes of serum tumor markers CEA,CA125,CA15-3,AFP,CA19-9 before and after chemotherapy and the evaluation of chemotherapy efficacy in patients with advanced breast cancer with liver metastasis.Methods Female patients with advanced breast cancer who received treatment in our hospital from September 2015 to October 2019 were screened.According to the replacement of chemotherapy regimens,the effective experimental data of 58 cases were determined.The levels of tumor markers before and after chemotherapy and the features of imaging in all cases were analyzed retrospectively.The patients were divided into remission group,stable group and progressive group by imaging evaluation.The relationship between the changes of tumor markers before and after chemotherapy and the efficacy of chemotherapy was analyzed,and the consistency of tumor markers and computed tomography(CT)in evaluating the efficacy of chemotherapy was analyzed.Results According to the efficacy evaluation criteria of solid tumors,13 cases were in remission group,21 cases were in stable group,and 24 cases were in advanced group.Comparison among multiple groups showed that the changes of CEA,CA125,and CA15-3 were related to the evaluation of chemotherapy efficacy,with statistical significance(P<0.05).The changes of CEA,CA125 and CA15-3 in the remission group and the progressive group were consistent with the evaluation of CT chemotherapy efficacy(Kappa=0.557,Kappa=0.525,Kappa=0.656,P<0.05).Conclusion The changes of CEA,CA125 and CA15-3 were related to the efficacy of chemotherapy in patients with liver metastasis of advanced breast cancer.The changes of CEA,CA125 and CA15-3 were in good agreement with CT evaluation of chemotherapy efficacy in remission group and progression group.