胆管癌免疫微环境特点与免疫检查点抑制剂治疗进展

Characteristics of immune microenvironment and progress of immune checkpoint inhibitors to cholangiocarcinoma treatment

胆管癌恶性程度高,手术切除率低,对放化疗不敏感,是预后较差的消化道恶性肿瘤之一。尽管近年来免疫检查点抑制剂(ICIs)治疗肿瘤取得了巨大的成功,但胆管癌患者对免疫治疗的客观反应率低,这与其免疫微环境的复杂性和多样性密不可分。因此,了解胆管癌免疫微环境的组成特点,并针对其免疫微环境靶点进行调控,以及采取ICIs联合治疗策略,将是提高胆管癌免疫疗效的一个重要研究方向。

Cholangiocarcinoma is a highly malignant disease with low surgical resection rate.It’s resistant to chemoradiotherapy and the prognosis of cholangiocarcinoma is poor.Although immune checkpoint inhibitors(ICIs)have achieved great success in tumor therapy in recent years,patients with cholangiocarcinoma have a poor response to immunotherapy,because of the complexity and diversity of immune microenvironment.Therefore,understanding the composition and characteristics of the immune microenvironment of cholangiocarcinoma,regulating targets in immune microenvironment,and adopting ICIs combined therapy,is important for immunotherapy for cholangiocarcinoma.