摘要
A new alkylpyrrole derivative,fusariumin A(1),was isolated from the culture broth of the fungus Fusarium sp.The absolute configuration of fuasiumin A has been established as(2'R,3'R)using a combination of RDC(residual dipolar coupling)-based NMR and DFT-supported chiroptical spectroscopy.It is worth to note that in this study without the aid of the RDC analysis,an unambiguous determination of configuration and conformation was not feasible due to the excessive conformational possibilities of this open-chain compound.
基金
Support by the National Natural Science Foundation of China(U1132607)to J.K.L.
the DFG(Forschergruppe FOR 934)to C.G
as well as the Chinese/German foundation(GZ1104)to H.S.and C.G.is acknowledged.
