摘要
Two new sterpurane sesquiterpenoids named sterpurol D(1)and sterpurol E(2),and one skeletally new sesquiterpene,cryptomaraone(3),bearing a 5,6-fused bicyclic ring system,along with five known ones,sterpurol A(4),sterpurol B(5),paneolilludinic Acid(6),murolane-2α,9β-diol-3-ene(7)and(-)-10,11-dihydroxyfarnesol(8)were isolated from an endolichenic fungus Cryptomarasmius aucubae.The structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS data.The absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation,as well as the biosynthetic consideration.Additionally,compounds 1,2,4-6,and 8 showed significant nitric oxide(NO)production inhibition in Lipopolysaccharide(LPS)-induced BV-2 microglial cells with the IC50 values ranging from 9.06 to 14.81μM.
基金
This work was financed by the National Natural Science Foundation of China(Grant Nos.21702169,22077102).
