摘要
Just one day after the official announcement for the end of H1N1 influenza by WHO,Kumarasamy et al.(2010)reported the emergence of a new global health problem,which was caused by Gram-negative Enterobacteriaceae with resistance to a broad range of beta-lactam antibiotics due to the presence of blaNDM-1 that encodes NDM-1,which inactivates allβ-lactam antibiotics.Now,the NDM-1 superbugs have been identified in multiple countries,including India,Pakistan,UK,USA,Japan,Brazil,Canada,Australia,France,Holland and China.A Belgian patient who was infected in Pakistan following a car accident became the first known fatality from NDM-1.NDM-1 belongs to metallo-β-lactamase(MBL),which is a characterized family of carbapenem antibiotics inactivating enzymes.However,the broad resistance to currently available antibiotics and the strong capability of contemporary horizontal gene transfer(HGT)bring the threat from NDM-1 bacteria into top news throughout the world.In the neverstopped game between human being and pathogens,we are in check again.
