G蛋白偶联受体在糖尿病视网膜病变发病过程中的作用

Role of G protein coupled receptors in the pathogenesis of diabetic retinopathy

糖尿病视网膜病变(DR)是糖尿病微血管病变表现之一,也是全球范围内视力丧失的主要原因。目前,临床上主要通过玻璃体内注射抗血管内皮生长因子药物治疗DR,但是部分患者会出现耐受性和不良反应,寻找新的治疗靶点和药物迫在眉睫。G蛋白偶联受体(G protein-coupled receptors,GPCR)是人体内最大的膜受体蛋白家族,在细胞信号转导中发挥重要作用。越来越多的研究表明,GPCR参与了DR病理生理过程。本文就GPCR在DR发病过程中的作用展开综述。

Diabetic retinopathy(DR)is one of the manifestations of diabetic microangiopathy and the main cause of vision loss worldwide.At present,clinical treatment is mainly through intravitreal injection of anti-vascular endothelial growth factor drugs,but some patients will experience tolerance and adverse reactions.It is urgent to find new therapeutic targets and drugs.G protein-coupled receptors(GPCR)are the largest family of membrane receptor proteins in the human body and play an important role in cell signal transduction.More and more studies have shown that GPCR is involved in the pathophysiological process of DR.This article reviews the role of GPCR in the pathogenesis of DR.