摘要
A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L.led to the isolation and char-acterization of a new pyrrole alkaloid,named lagerindicine(1),along with four known compounds(2-5).Their structures were elucidated by the detailed spectroscopic analysis and comparison with literature data,whereas the structure,in par-ticularly,the absolute configuration(AC)of 1,was firmly determined by total synthesis.All the isolates were evaluated for their cytotoxic effects against human colon cancer cell(HCT-116),and compound 3 exhibited weak cytotoxicity with IC50 value of 28.4μM.
基金
supported by the National Natural Science Foundation of China(NSFC)(Nos.81991521,41676073)
the National Key Research and Development Program of China(No.2018YFC0310903)
the Drug Innovation Major Project(No.2018ZX09711-001-001-009)
the SKLDR/SIMM Project(No.SIMM1903ZZ-04)
Changsha Engineering Technology Research Center of Woody flower(kq1907081).