Protein targets for structure-based antiMycobacterium tuberculosis drug discovery

Mycobacterium tuberculosis,which belongs to the genus Mycobacterium,is the pathogenic agent for most tuberculosis(TB).As TB remains one of the most rampant infectious diseases,causing morbidity and death with emergence of multi-drug-resistant and extensively-drugresistant forms,it is urgent to identify new drugs with novel targets to ensure future therapeutic success.In this regards,the structural genomics of M.tuberculosis provides important information to identify potential targets,perform biochemical assays,determine crystal structures in complex with potential inhibitor(s),reveal the key sites/residues for biological activity,and thus validate drug targets and discover novel drugs.In this review,we will discuss the recent progress on novel targets for structure-based anti-M.tuberculosis drug discovery.