摘要
The CCR4-NOT complex is a highly conserved,multifunctional machinery controlling mRNA metabolism.Its components have been implicated in several aspects of mRNA and protein expression,including transcription initiation,elongation,mRNA degradation,ubiquitination,and protein modification.In this review,we will focus on the role of the CCR4-NOT complex in mRNA degradation.The complex contains two types of deadenylase enzymes,one belonging to the DEDD-type family and one belonging to the EEP-type family,which shorten the poly(A)tails of mRNA.We will review the present state of structure-function analyses into the CCR4-NOT deadenylases and summarize current understanding of their roles in mRNA degradation.We will also review structural and functional work on the Tob/BTG family of proteins,which are known to interact with the CCR4-NOT complex and which have been reported to suppress deadenylase activity in vitro.
基金
This work was supported by the National Basic Research Program(973 Program)(Grant No.2007CB914301)
the National Natural Science Foundation of China(Grant Nos.30221003 and 30770438)
This work was also supported in part by the Global COE Program(Integrative Life Science Based on the Study of Biosignaling Mechanisms),MEXT,Japan.
