摘要
One undescribedamide,pipermullesine A,twoundescribed isoquinoline alkaloids,pipermullesinesBand C,and six undescribed dipeptides,pipermullamides A–F,along with 28 known compounds,were isolated from the aerial parts of Piper mullesua.The structures of the undescribed compounds were elucidated based on the analysis of 1D and 2D NMR and MS data.Furthermore,the structures of pipermullesines A–Cwere confirmed by single crystal X-ray diffraction analysis.All isolates were evaluated for inhibitory activity against platelet aggregation induced by thrombin(IIa)or platelet-activating factor(PAF).(-)-Mangochinine,pellitorine,and(2E,4E)-N-isobutyl-2,4-dodecadienamide showed weak inhibitory activity against rabbit platelet aggregation induced by PAF,with IC_(50)values of 470.3μg/mL,614.9μg/mL,and 579.7μg/mL,respectively.
基金
This work was funded by the Southeast Asia Biodiversity Research Institute,Chinese Academy of Sciences(Y4ZK111B01)
the Natural Science Foundation of Yunnan Province,China(2011FZ205)
the International Partneship Program of Chinese Academy of Sciences(153631KYSB20160004)
the Key Laboratory of Ethnomedicine(Minzu University of China)of Ministry of Education of China(KLEM-ZZ201806)
the National Natural Science Foundation of China(31761143001&31161140345).
