摘要
Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11–C14 para quinone.The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid,miltionone I and deoxyneocrptotanshinone.Following our synthetic route,15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.
基金
The work was financially supported by the foundations from NSFC(81373291)to Dr.G.Xu,NSFC(21372229)to Dr.H.B.Qin
from Foundation of Kunming Institute of Botany(KIB2017007)to Dr.G.Xu.
