双歧杆菌对支气管哮喘儿童肺功能及血清IFN-γ、IL-4的影响

Effect of Bifidobacterium on Pulmonary Function and Serum IFN-γ,IL-4 levels in Children with Bronchial Asthma

目的:探讨双歧杆菌辅助治疗儿童支气管哮喘的临床疗效及其对肺功能、血清IFN-γ、IL-4的影响。方法:选取2018年7月~2020年2月某院收治的72例支气管哮喘急性发作期患儿为研究对象,随机分为对照组和观察组。对照组予常规治疗,观察组联用双歧杆菌三联活菌片,观察并比较两组患儿症状、体征消失时间、肺功能以及血清IFN-γ、IL-4水平。结果:治疗后两组患儿肺功能指标FEV1、FEV1/FVC、MEF25%及MEF50%均有明显改善(P<0.05),且观察组优于对照组(P<0.05);两组患儿临床症状、体征消失时间无明显差异(P>0.05);治疗后两组患儿血清IFN-γ水平明显升高、IL-4水平明显下降(P<0.05);但两组组间比较无明显差异(P>0.05)。结论:与哮喘常规治疗相比,双歧杆菌联合治疗方案能够有效改善哮喘患儿肺功能,但对哮喘急性发作症状体征持续时间及血清IFN-γ、IL-4水平无明显影响。

Objective:To explore the clinical efficacy of Bifidobacterium in children with bronchial asthma and its influence on lung function,serum IFN-γand IL-4.Methods:72 children with acute exacerbation asthma from July 2018 to February 2020 were selected as the research objects and randomly divided into control group and observation group.The control group was given conventional treatment,and the observation group was combined with Bifidobacterium.The symptoms and signs disappeared time,lung function indexes and serum IFN-γ,IL-4 levels of the two groups were observed and compared.Results:FEV1,FEV1/FVC,MEF25%and MEF50%of the two groups were significantly improved after treatment(P<0.05),and the observation group was better than the control group(P<0.05).There was no significant difference in the disappearance time of clinical symptoms and signs between the two groups(P>0.05).The serum IFN-γlevel was significantly increased and IL-4 level was significantly decreased in the two groups after treatment(P<0.05),but there was no significant difference between the two groups(P>0.05).Conclusion:Compared with conventional treatment of asthma,Bifidobacterium combined therapy has no significant effect on the duration of symptoms and signs and serum IFN-γ,IL-4 levels,but it can effectively improve the lung function of children with asthma.