淫羊藿苷促进骨关节炎软骨修复机制的研究进展

Research Progress on Mechanisms of Icariin Repairing Cartilage in Osteoarthritis

骨关节炎(osteoarthritis, OA)是一种由多种因素引起的以关节软骨退行性改变为主要特点的骨关节疾病。该病的发病机制目前尚不明确,主要病理变化包括炎性细胞因子的增多、细胞外基质的降解和软骨细胞的凋亡等。淫羊藿苷(icariin, ICA)是中药淫羊藿的主要有效活性单体,大量研究表明,ICA可以促进软骨细胞的增殖和抑制软骨细胞的凋亡;可以减少OA中炎性细胞因子的活性,从而减少细胞外基质的降解;可以诱导间充质干细胞成软骨分化和迁移,从而修复软骨缺损的病变。就近5年关于ICA促进软骨修复机制的研究作一综述,为ICA治疗OA的进一步研究提供参考依据。

Osteoarthritis(OA) is a kind of bone and joint diseases mainly characterized by degenerative disease of articular cartilage caused by a variety of factors. The pathogenesis of the disease is still unclear, and the main pathological changes include the increase of inflammatory cytokines, the degradation of extracellular matrix and the apoptosis of chondrocytes. Icariin(ICA) is the main active monomer of Yinyanghuo(Epimedii Folium). A large number of studies have shown that ICA can promote the proliferation of chondrocytes and inhibit the apoptosis of chondrocytes. It can reduce the activity of inflammatory cytokines in OA, and reduce the degradation of extracellular matrix. It can induce chondrogenic differentiation and migration of mesenchymal stem cells to repair cartilage defects. This review is based on the mechanism of ICA repairing cartilage in the nearly 5 years, providing reference for further research on ICA in the treatment of OA.