不同组织学类型乳腺癌的临床病理特征分析

Analysis of Clinicopathological Characteristics of Different Histological Types of Breast Cancer

目的对不同组织学类型乳腺癌的临床病理特征进行分析。方法回顾性分析我院709例乳腺癌患者临床资料,分为浸润性导管/小叶混合癌(IDC-L)组、浸润性小叶癌(ILC)组与浸润性导管癌(IDC)组,分析三组患者一般资料、临床病理特征、蛋白表达情况。结果共纳入709例乳腺癌患者,其中IDC-L组为9例,ILC组为22例,IDC组为678例;三组患者年龄是IDC-L、ILC、IDC的临床病理特征(P<0.05),而绝经情况、孕次、产次比较均无统计学意义(P>0.05);三组患者淋巴结状态比较均无统计学意义(P>0.05),而病灶大小、多中心病灶、淋巴血管入侵、分子亚型是IDC-L、ILC、IDC的临床病理特征(P<0.05);三组患者蛋白表达[雌激素受体(ER)状态、孕激素受体(PR)状态、人类表皮生长因子受体-2(HER2)状态、增殖指数(Ki67)]是IDC-L、ILC、IDC的临床病理特征(P<0.05)。结论IDC-L患者临床病理特征与ILC差异较小,而与IDC患者差异较大。

Objective To analyze the clinicopathological characteristics of different histological types of breast cancer.Methods The clinical data of 709 patients with breast cancer in the hospital were retrospectively analyzed.The patients were divided into the invasive ductal/lobular mixed carcinoma(IDC-L)group,the invasive lobular carcinoma(ILC)group,and the invasive ductal carcinoma(IDC)group.General data,clinicopathological characteristics,and protein expression were analyzed among the three groups.Results A total of 709 patients with breast cancer were enrolled,including 9 cases in IDC-L group,22 cases in ILC group,and 678 cases in IDC group.The age of patients in the three groups was a clinicopathological characteristic of IDC-L,ILC,and IDC(P<0.05),but there were no statistically significant differences in the menopausal status,gravidity and parity(P>0.05).The comparison of lymph node status of the three groups of patients was not statistically significant(P>0.05),while the lesion size,multi-center lesions,lymphatic vascular invasion,and molecular subtypes were the clinicopathological characteristics of IDC-L,ILC,and IDC(P<0.05).The protein expressions of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER2),and proliferation index(Ki67)of the three groups of patients were the clinicopathological characteristics of IDC-L,ILC,and IDC(P<0.05).Conclusion The clinicopathological characteristics of patients with IDC-L are slightly different from those of patients with ILC,but significantly different from those of patients with IDC.