尿液AD7c-NTP与阿尔茨海默病

Urine AD7C-NTP and Alzheimer's Disease

阿尔茨海默病(AD)是一种以进行性认知功能障碍为特征的中枢神经系统退行性疾病,是导致老年人死亡的第五大病因,目前尚无特殊有效的治疗。AD7c-NTP是一种与AD神经元变性密切相关的跨膜磷蛋白,它能促进神经炎症的萌发与细胞凋亡,在早期AD患者的脑组织、脑脊液和尿液中选择性升高,而在多发性硬化、抑郁症及其他慢性疾病中未发现类似特异性升高。尿液AD7c-NTP诊断AD的灵敏度及特异度与脑脊液相似,并且其含量与痴呆严重程度呈正相关。此外,因尿液检测具有易操作、无创、经济、安全等优点,方便在临床中推广应用,在未来尿液AD7c-NTP有可能成为筛查及诊断AD的一种特异性生物标志物。

Alzheimer's disease(AD)is a central nervous system degenerative disease characterized by progressives cognitive impairment,which leads to the fifth major cause of death among the elderly,and there is no special effective treatment yet.AD7C-NTP is a transmembrane phosphoprotein closely related to the degeneration of AD neurons,which can promote the germination of neuroinflammation and apoptosis.It is selectively elevated in the brain tissue,cerebrospinal fluid and urine of patients with AD in the early stage.However,similar specific increase has not been found in multiple sclerosis,depression,and other chronic diseases.The sensitivity and specificity of AD7C-NTP in urine for the diagnosis of AD were similar to those in cerebrospinal fluid,and the content of AD7C-NTP in urine was positively correlated with the severity of dementia.In addition,urine detection is easy to operate,non-invasive,economic,safe,and other advantages,convenient for clinical application,urine AD7C-NTP may become a specific biomarker for screening and diagnosis of AD in the future.