多层螺旋CT联合CA153、CEA及CA199检测对肺癌临床诊断价值分析

Clinical Diagnostic Value of Multi-slice Spiral CT(MSCT)Combined with CA153,CEA,and CA199 Detection for Lung Cancer

目的分析多层螺旋CT(MSCT)联合CA153、CEA及CA199检测对肺癌临床诊断价值。方法选取本院2017年6月至2019年8月收治的59例肺癌患者,均经术后病理检查证实,另选取同期在本院进行体检的健康人群59例作为研究对象。对患者所得MSCT图像进行分析,了解不同人群血清中CA153、CEA及CA199表达情况并计算MSCT、CA153、CEA、CA199单独以及四者联合检查对肺癌的诊断灵敏性、特异性、准确性。结果肺癌患者血清中CA153、CEA及CA199表达情况均明显高于健康人群(P<0.05)。MSCT检查对肺癌诊断灵敏性、特异性、准确性分别为79.66%、72.88%、76.27%,CA153诊断分别为49.15%、67.79%、59.32%;CEA检查分别为57.62%、76.27%、67.79%,CA199分别为59.32%、77.96%、69.49%,四种检查两两之间灵敏性、特异性、准确性比较差异无统计学意义(P>0.05),四种联合检查诊断灵敏性、特异性、准确性分别为59.32%、98.30%、100.00%,明显高于四者单独检查(P<0.05)。结论MSCT联合CA153、CEA及CA199检测对肺癌临床诊断价值高,可有效提高对肺癌的诊断灵敏性、特异性、准确性,对肺癌早期诊断具有重要的价值。

Objective To analyze the clinical diagnostic value of multi-slice spiral CT(MSCT)combined with CA153,CEA and CA199 detection for lung cancer.Methods 59 patients with lung cancer treated in our hospital from June 2017 to August 2019 were confirmed by postoperative pathological examination,and 59 healthy people underwent physical examination in our hospital during the same period were selected as the research objects.The MSCT images of patients were analyzed to understand the expression of CA153,CEA,and CA199 in the serum of different people,and the sensitivity,specificity and accuracy of MSCT,CA153,CEA,CA199 alone and the combined examination in the diagnosis of lung cancer were calculated.Results The expression of CA153,CEA,and CA199 in the serum of patients with lung cancer was significantly higher than that in healthy people(P<0.05).The diagnostic sensitivity,specificity,and accuracy of MSCT for lung cancer were 79.66%,72.88%,and 76.27%,diagnostic sensitivity,specificity,and accuracy of CA153 for lung cancer were 49.15%,67.79%,and 59.32%,diagnostic sensitivity,specificity,and accuracy of CEA examination for lung cancer were 57.62%,76.27%,and 67.79%,respectively,and the diagnostic sensitivity,specificity,and accuracy of CA199 for lung cancer were 59.32%,77.96%,and 69.49%.There was no significant difference in diagnostic sensitivity,specificity,and accuracy in the four examinations(P>0.05).The diagnostic sensitivity,specificity,and accuracy of the four combined examinations for lung cancer were 59.32%,98.30%,and 100.00%,which were significantly higher than those of the four separate examination(P<0.05).Conclusion MSCT combined with CA153,CEA,and CA199 has a high clinical diagnosis value for lung cancer,which can effectively improve the diagnostic sensitivity,specificity and accuracy for lung cancer and has important value in the early diagnosis of lung cancer.