慢性胃炎患者唾液Hp抗体IgG和粪便Hp抗原检测结果的临床意义

Clinical Significance of Salivary Helicobacter Pylori(Hp)Antibody IgG and Fecal Hp Antigen Detection in Patients with Chronic Gastritis

【目的】观察慢性胃炎患者唾液幽门螺旋杆菌(Hp)抗体IgG(HpIgG)和粪便Hp抗原检测结果的临床意义。【方法】在本院接受治疗的慢性胃炎患者为观察组,同时选取同期在本院体检的健康成年人作为对照组。观察两组研究对象唾液HpIgG和粪便Hp抗原检测结果,比较两组胃蛋白酶原(PG)Ⅰ、PGⅡ、胃泌素17(G-17),细胞因子[超敏C反应蛋白(hs-CRP)、白细胞介素-18(IL-18)、IL-6]水平的差异,分析慢性胃炎患者唾液HpIgG和粪便Hp抗原检测结果与PGⅠ、PGⅡ、G-17、细胞因子水平的相关性。【结果】观察组患者的唾液HpIgG、粪便Hp抗原检测的阳性率分别为72.00%(72/100)和45.00%(45/100),均高于对照组(P<0.01);观察组患者的PGⅠ、PGⅡ水平低于对照组(P<0.01),G-17水平高于对照组(P<0.01);观察组患者的IL-18、IL-6、hs-CRP水平均高于对照组(P<0.01)。慢性胃炎患者唾液HpIgG和粪便Hp抗原阳性率与PGⅠ、PGⅡ水平呈负相关,与G-17、IL-18、IL-6、hs-CRP水平呈正相关(P<0.05)。【结论】慢性胃炎患者唾液HpIgG和粪便Hp抗原检测阳性率较高,且与胃蛋白酶和细胞因子水平相关。

【Objective】To reveal the clinical significance of helicobacter pylori(Hp)antibody IgG(HpIgG)detection in saliva and Hp antigen in feces of patients with chronic gastritis.【Methods】The patients with chronic gastritis who were treated in our hospital were selected as the observation group and healthy adults who had physical examination in our hospital during the same period were selected as the control group.The results of HpIgG in saliva and Hp antigen in feces of the two groups were observed.The differences of pepsinogen(PGⅠand PGⅡ),G-17(gastrin 17),cytokine hypersensitive C-reaction protein(hs-CRP)and cytokines(IL-18 and IL-6)levels between the two groups were compared.The correlation between the results of HpIgG in saliva and Hp antigen in feces of patients with chronic gastritis and the levels of PGⅠ,PGⅡ,G-17 and cytokines was analyzed.【Results】In the observation group,the positive rates of HpIgG in saliva and Hp antigen in feces were 72.00%and 45.00%,respectively,which were higher than those in the control group(P<0.01).The levels of PGⅠand PGⅡin the observation group were lower than those in the control group,while the level of G-17 in the observation group was higher than that in the control group(P<0.01).The levels of IL-18,IL-6 and hs-CRP in the observation group were higher than those in the control group(P<0.01).The positive rates of HpIgG in saliva and Hp antigen in feces of patients in the observation group were negatively correlated with the levels of PGⅠand PGⅡ,and positively correlated with the levels of G-17,IL-18,IL-6 and hs-CRP(P<0.05).【Conclusion】The positive rate of HpIgG in saliva and Hp antigen in feces is higher in patients with chronic gastritis,and it is related to pepsin and cytokine levels.