醒脑静联合依达拉奉治疗脑出血对患者VEGF、BNP及和肽素水平的影响

Effect of Xingnaojing Combined with Edaravone on the Levels of VEGF,BNP and Copeptin in Patients with Cerebral Hemorrhage

【目的】探讨醒脑静联合依达拉奉治疗脑出血对患者血管内皮生长因子(VEGF)、脑钠肽(BNP)及和肽素水平的影响。【方法】本院收治的脑出血患者96例,根据治疗方法不同分为对照组和观察组。两组均给予常规治疗外,对照组患者采用醒脑静治疗,观察组患者采用醒脑静联合依达拉奉治疗。比较两组患者治疗后的临床疗效。【结果】观察组患者总有效率为95.83%(46/48),明显高于对照组的75.00%(36/48),且差异有显著性(P<0.05)。治疗前两组各指标水平比较差异均无显著性(P>0.05)。治疗后,两组内皮素(ET)、VEGF、BNP、和肽素以及铁蛋白(SF)、一氧化氮(NO)、丙二醛(MDA)水平均低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。治疗前,两组神经功能缺损量表(NIHSS)评分、蒙特利尔认知评估量表(MoCA)评分及日常生活活动量表(ADL)评分比较差异均无显著性(P>0.05)。治疗后,两组NIHSS评分低于治疗前,MoCA、ADL评分高于治疗前,且观察组治疗后NIHSS、MoCA、ADL评分优于对照组(P<0.05)。【结论】醒脑静联合依达拉奉治疗可提高脑出血的疗效,降低患者BNF、和肽素、SF、NO、MDA水平,改善患者神经功能,值得临床推广运用。

【Objective】To analyze the effect of Xingnaojing combined with edaravone on the levels of vascular endothelial growth factor(VEGF),brain natriuretic peptide(BNP)and copeptin in patients with cerebral hemorrhage.【Methods】A total of 96 patients with cerebral hemorrhage were selected and divided into the control group and the observation group according to different treatment methods.Both groups were given conventional treatments.Patients in the control group were treated with Xingnaojing alone,while patients in the observation group were treated with Xingnaojing assisted by edaravone.The clinical efficacy of the two groups were analyzed after treatment.【Results】The total effective rate of patients in the observation group was 95.83%(46/48),which was higher than that of the control group 75.00%(36/48,P<0.05).There was no significant difference in the levels of indicators between the two groups before treatment(P>0.05).After treatment,the levels of ET,VEGF,BNP,copeptin,SF,NO,and MDA in the two groups were lower than those before treatment;and the above indicators in the observation group were lower than those in the control group after treatment.The difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference between the two groups in terms of of NIHSS,MoCA(the Montreal cognitive assessment scale),and ADL(activity of daily living scale)scores(P>0.05).After treatment,the NIHSS scores of the two groups were lower than those before treatment,and MoCA and ADL scores were higher than those before treatment.The NIHSS,MoCA and ADL scores of the observation group after treatment were better than those of the control group(P<0.05).【Conclusion】Xingnaojing combined with edaravone therapy can improve the efficacy of cerebral hemorrhage,reduce the levels of BNF,copeptin,SF,NO,and MDA in patients,and improve the neurological function of patients.It is worthy of clinical application.