血清IL-38、sTREM-1、IL-6水平与COPD病情变化的关系

Relationship of Serum IL-38,sTREM-1,and IL-6 Levels with Status of Chronic Obstructive Pulmonary Disease

【目的】探讨慢性阻塞性肺疾病(COPD)患者血清白细胞介素-38(IL-38)、白细胞介素-6(IL-6)、可溶性髓系触发受体-1(sTREM-1)水平的变化及其意义。【方法】100例COPD患者(COPD组)、100例健康体检无肺部疾患的志愿者作为对照组;检测比较两组的血清IL-38、sTREM-1、IL-6水平,并按照COPD患者病情分为稳定期组、急性发作期组进行分层分析。【结果】COPD组患者的血清IL-38、sTREM-1、IL-6水平显著高于对照组,且差异具有显著性(P<0.05);急性发作期COPD患者的血清IL-38、sTREM-1、IL-6水平显著高于稳定期患者(P<0.05);急性发作期COPD患者的第1秒用力呼气容积(FEV1)占预计值百分比(FEV1%pred)、FEV1/用力肺活量(FVC)低于稳定期患者,且差异有显著性(P<0.05);急性发作期的COPD患者CAT评分高于稳定期组(P<0.05);COPD患者CAT评分与IL-38、sTREM-1、IL-6水平均呈显著的正相关关系(P<0.05)。【结论】COPD患者血清IL-38、sTREM-1、IL-6水平升高明显,且与疾病严重程度有关。

【Objective】To investigate the changes of serum interleukin-38(IL-38),interleukin-6(IL-6)and soluble myeloid receptor-1(sTREM-1)in patients with chronic obstructive pulmonary disease(COPD)and their significance.【Methods】A total of 100 patients with COPD were selected as the COPD group while 100 healthy volunteers without lung disease were selected as the control group.Serum IL-38,sTREM-1,and IL-6 levels were measured in both groups.According to COPD condition,patients were divided into a stable phase group and an acute stratification group.【Results】The levels of serum IL-38,sTREM-1,and IL-6 in the COPD group were significantly higher than those in the control group(P<0.05).Serum IL-38,sTREM-1,IL-6 levels of patients in the acute stratification group were significantly higher than those of patients in the stable phase group(P<0.05).FEV1%pred(the forced expiratory volume in the first second as a percentage of the predicted value)and FEV1/FVC(forced vital capacity)in patients with acute exacerbation of COPD were lower than that in stable phase,with statistically significant difference(P<0.05).The CAT score of the acute stratification group was higher than that of the stable phase group(P<0.05).The CAT score of COPD patients was positively correlated with IL-38,sTREM-1 and IL-6 levels(P<0.05).【Conclusion】The levels of serum IL-38,sTREM-1,and IL-6 in patients with COPD increased significantly and were related to the severity of the disease.