摘要
Studies of dietary restriction’s effect on lifespan extension in C.elegans and other model organisms have greatly expanded our knowledge about genetic network underlying stress response,ageing,and ageing related diseases.Among key molecules and signaling pathways implicated are Foxo(daf-16)and Foxa(pha-4)transcriptional factors and the nutrient sensing insulin/TOR pathway(Wolkow et al.,2000;Panowski et al.,2007;Hansen et al.,2008).
