Neuronal stem cells in the central nervous system and in human diseases

The process of cortical expansion in the central nerv-ous system is a key step of mammalian brain devel-opment to ensure its physiological function.Radial glial(RG)cells are a glial cell type contributing to this pro-gress as intermediate neural progenitor cells responsi-ble for an increase in the number of cortical neurons.In this review,we discuss the current understanding of RG cells during neurogenesis and provide further in-formation on the mechanisms of neurodevelopmental diseases and stem cell-related brain tumorigenesis.Knowledge of neuronal stem cell and relative diseases will bridge benchmark research through translational studies to clinical therapeutic treatments of these dis-eases.