摘要
Recent applications of new tools for genome-wide mapping of long-range and spatial interactions have shed light onto the fundamental mechanisms of three dimensional chromatin organizations in pluripotent stem cells and their derivatives.Pluripotent stem cells(PSCs),including embryonic stem cells(ESCs)and induced pluripotent stem cells(iPSCs),can pro-liferate limitlessly and differentiate into many types of somatic cells in vitro,providing great promise for basic research and clinical therapy.
基金
G.-H.L.was supported by the National Laboratory of Biomacro-molecules,the 100 Talents Program of Chinese Academy of Sci-ences,a CIRM grant(No.TG2-01158)
a Glenn Foundation grant.J.Q.was supported by the AFAR/Ellison Medical Foundation.