Negative regulation of NLRP3 infl ammasome signaling

Infl ammasomes are multiprotein complexes that serve as a platform for caspase-1 activation and interleukin-1β(IL-1β)maturation as well as pyroptosis.Though a number of infl ammasomes have been described,the NLRP3 inflammasome is the most extensively studied.NLRP3 inflammasome is triggered by a variety of stimuli,including infection,tissue damage and metabolic dysregulation,and then activated through an integrated cellular signal.Many regulatory mechanisms have been identifi ed to attenuate NLRP3 infl ammasome signaling at multiple steps.Here,we review the developments in the negative regulation of NLRP3 inflammasome that protect host from inflammatory damage.