产前不同类型阴道炎孕妇脐带血PCT、IL-6水平及与宫内感染发生情况分析

Relationship between the levels of umbilical cord blood procalcitonin and interleukin-6 of women with different types of vaginitis during pregnancy and their risk of intrauterine infection

目的:研究孕妇合并产前不同病型阴道炎患者脐带血降钙素原(PCT)、白介素-6(IL-6)水平与宫内感染关系。方法:将2018年1月-2019年12月本院行产前检查并分娩的122例孕妇纳为研究对象,发生宫内感染34例,检测研究对象脐带血血清PCT及IL-6水平、孕期阴道炎等情况,分析不同类型阴道炎与宫内感染关系。结果:宫内感染组及非感染组年龄、孕次、产次无差异(P>0.05),分娩周期、孕期阴道炎发生率、孕期性行为、围产期阴道检查次数、产程存在差异,血清IL-6(48.16±11.35ng/L)及PCT(51.16±12.44 pg/ml)高于非感染组(16.36±2.53 ng/L、31.25±7.89 pg/ml)(均P<0.05);孕期阴道炎产妇脐带血清IL-6(38.34±10.37 ng/L)及PCT水平(43.33±12.04 pg/ml)均高于非阴道炎产妇(19.87±4.15 ng/L、30.02±7.11 pg/ml)(均P<0.05);而滴虫性阴道炎(TV)、阴道假丝酵母菌病(VVC)、细菌性阴道病(BV)不同类型者与宫内感染、IL-6及PCT水平间均无差异(P>0.05)。结论:不同类型阴道炎均可能增加宫内感染发生风险,应重视并积极防治孕期阴道炎,降低宫内感染发生。

Objective: To investigate the relationship between the levels of umbilical cord blood procalcitonin(PCT) and interleukin-6(IL-6) of women with different types of vaginitis during pregnancy and their risk of intrauterine infection. Methods: 122 pregnant women were enrolled in this study from January 2018 to December 2019, which included 34 women with intrauterine infection in group A and 78 women without intrauterine infection in group B. The levels of umbilical cord blood PCT and IL-6 of these women were detected, and vaginitis situation of these women during pregnancy were analyzed. The relationship between different types of vaginitis and intrauterine infection status was analyzed. Results: There were no significant different in age, gravidity and parity of the women between group A and B(P>0.05). There were significant different in the gestational weeks, the incidence of vaginal vaginitis during pregnancy, sexual behavior situation during pregnancy, the number of perinatal vaginal examination, and the course of labor of the women between group A and B. The levels of serum IL-6(48.16±11.35 ng/L) and PCT(51.16±12.44 pg/ml) of the women in group A were significant higher than those(16.36±2.53 ng/L and 31.25±7.89 pg/ml) of the women in group B(all P<0.05). The levels of serum IL-6 and PCT in umbilical cord blood of the women in group A were 38.34±10.37 ng/L and 43.33±12.04 pg/ml, which were significant higher than those(19.87±4.15 ng/L and 30.02±7.11 pg/ml) of the women in group B(all P<0.05). In group A, the rate of intrauterine infection, and levels IL-6 and PCT had no significant different among the women with trichomonad vaginitis(TV), the women with vulvovaginal candidiasis(VVC), and the women with bacterial vaginosis(BV)(P>0.05). Conclusion: Different types of vaginitis may increase the risk of intrauterine infection, so it is great significance to actively prevent and treat vaginitis during pregnancy to reduce the incidence of intrauterine infection and improve maternal and infant outcomes.