摘要
We investigate the role of β-catenin signaling in the response of macrophage to lipopolysaccharide(LPS)using RAW264.7 cells.LPS rapidly stimulated cytosolic β-catenin accumulation.β-catenin-mediated transcription was showed to be required for LPS induced gene expression and cell migration.Mechanically,ERK activation-primed GSK3β inactivation by Akt was demonstrated to mediate the LPS induced β-catenin accumulation.Overall,our findings suggest that suppression of GSK3β by ERK stimulatesβ-catenin signaling therefore contributes to LPS induced cell migration in macrophage activation.
基金
supported by the Netherlands Organization for Scientific Research(NWO 918.66.066)
Netherlands Initiative for Regenerative Medicine and Centre for Biomedical Genetics
CSTC2012 jjjq1000
National Nature Science Foundation of China Grants 30900748 and 31171388(to H.H.).
