256层螺旋CT灌注成像参数在脑胶质瘤诊断中的应用价值

Application Value of 256 Slice Spiral CT Perfusion Imaging Parameters in the Diagnosis of Gliomas

本文探讨了256层螺旋CT灌注成像参数在脑胶质瘤诊断中的应用价值。选取91例脑胶质瘤患者纳入本研究,均给予256层螺旋CT灌注成像检查,同时采用免疫组化染色法检测病灶血管内皮生长因子(VEGF)表达。与对侧正常脑组织比较,病灶区CT灌注成像参数脑血流量(CBF)、脑血容量(CBV)和毛细血管表面通透性(PS)明显较高(P<0.05);高级别病灶CT灌注成像参数CBF、CBV、PS及VEGF表达光密度值明显高于低级别病灶(P<0.05);CBF、CBV与VEGF表达光密度呈正相关(P<0.05);CBF、CBV和PS鉴别高级别病灶的AUC分别为0.885、0.877和0.792(P<0.05)。256层螺旋CT灌注成像参数在低、高级别脑胶质瘤鉴别中有较好的应用价值,并且与VEGF表达存在相关性,可间接反映血管生成情况。

The purpose of this study was to investigate the application value of 256 slice spiral CT perfusion imaging parameters in the diagnosis of glioma.A total of 91 patients with glioma were selected as research subjects.All patients were examined with 256 slice spiral CT perfusion imaging,and the expression of vascular endothelial growth factor(VEGF)was detected by immunohistochemistry.Compared with the contralateral normal brain tissue,the cerebral blood flow(CBF),cerebral blood volume(CBV)and capillary surface permeability(PS)in the lesion area were significantly higher(P<0.05).The CT perfusion imaging parameters CBF,CBV,PS and optical density values of VEGF in high-grade lesions were significantly higher than those of low-grade lesions(P<0.05).There was a positive correlation between CBF,CBV and the optical density of VEGF expression(P<0.05).The AUC of CBF,CBV and PS in differentiating high-grade lesions were 0.885,0.877 and 0.792(P<0.05).256 slice spiral CT perfusion imaging parameters have good application value in the differential diagnosis of low and high-grade gliomas,and are correlated with VEGF expression,which can indirectly reflect angiogenesis.