颈动脉超声筛查脑卒中高危人群颈动脉易损斑块与ACR、ALBU的相关性研究

Study on the Correlation between Carotid Artery Vulnerable Plaque and ACR and ALBU in High-Risk Population of Stroke Based on Carotid Ultrasound Screening

本研究探讨颈动脉超声筛查脑卒中高危人群颈动脉易损斑块与尿微量白蛋白/肌酐(ACR)、尿微量白蛋白(ALBU)的相关性。选取307例脑卒中高危患者,根据颈动脉超声检查将其分为:无颈动脉斑块组112例、颈动脉稳定斑块组45例和颈动脉易损斑块组150例。研究发现,各组年龄≥60岁占比、有脑卒中家族史占比以及颈动脉内中膜厚度(IMT)、ACR、ALBU水平对比存在明显差异(P<0.05);脑卒中高危人群IMT与ACR、ALBU呈正相关(P<0.05);年龄、脑卒中家族史、IMT、ACR、ALBU均为脑卒中高危人群颈动脉斑块发生的影响因素(P<0.05);IMT、ACR、ALBU联合在颈动脉斑块诊断、易损斑块鉴别诊断方面均具有较高效能。这些结果可以证实,脑卒中高危人群IMT与ACR、ALBU呈正相关,早期联合IMT、ACR、ALBU检查,可辅助临床诊断颈动脉斑块、鉴别诊断易损斑块。

The purpose of this study was to explore the correlation between carotid artery ultrasound screening of carotid artery vulnerable plaque and urinary microalbumin/creatinine(ACR)and urinary microalbumin(ALBU)in people at high risk of stroke.According to the carotid ultrasound examination,307 selected patients with high risk of stroke were divided into:112 cases without carotid plaque,45 cases with stable carotid plaque and 150 cases with carotid artery vulnerable plaque.The study found that there were significant differences in the proportions of age≥60 years old,the proportion of family history of stroke,and the comparison of carotid artery intima-media thickness(IMT),ACR,and ALBU levels(P<0.05).IMT and ACR and ALBU are positively correlated(P<0.05).Age,family history of stroke,IMT,ACR,and ALBU are all influencing factors of carotid plaque in people at high risk of stroke(P<0.05).IMT,ACR,and ALBU are combined in the diagnosis of carotid plaque and the differential diagnosis of vulnerable plaque have high efficiency.These results can confirm that IMT is positively correlated with ACR and ALBU in high-risk populations of stroke.Early combined IMT,ACR,and ALBU examination can assist clinical diagnosis of carotid plaque and differential diagnosis of vulnerable plaque.