应用柴胡疏肝散联合奥美拉唑和莫沙必利治疗胃食管反流病的可行性

Feasibility of treatment of gastroesophageal reflux disease with Chaihu Shugan Powder combined with omeprazole and mosapride

目的:研究探讨应用柴胡疏肝散联合奥美拉唑和莫沙必利治疗胃食管反流病的可行性和有效性。方法:收集我院收治的110例胃食管反流病患者(2016年6月至2017年6月),按照随机数字表法随机分为各由55例组成的对照组与观察组,对照组治疗时选择奥美拉唑+莫沙必利,观察组治疗时选择奥美拉唑+莫沙必利+柴胡疏肝散,比较两组的临床疗效、症状缓解时间、中医证候积分、生活质量评分、不良反应发生率。结果:组间临床疗效比较,观察组的总有效率高于对照组(P<0.05);组间恶心呕吐、嗳气反酸、腹痛等症状缓解时间比较,观察组均短于对照组(P<0.05);胃脘胀痛、嗳气反酸、咽异感、大便溏稀等中医证候积分比较,治疗后,观察组均低于对照组(P<0.05);躯体功能、心理健康、社会关系、生活环境等方面生活质量评分比较,治疗后,观察组均高于对照组(P<0.05);组间不良反应比较,观察组与对照组的总发生率分别为7.27%、3.64%,组间差异无统计学意义(P>0.05)。结论:应用柴胡疏肝散与西药(奥美拉唑、莫沙必利)联合方案治疗,可有效提高胃食管反流病的临床疗效,加快症状缓解速度,改善患者生活质量,且患者用药后不良反应少,安全性可靠。

Objective:To study the feasibility and efficacy of Chaihu Shugan Powder combined with omeprazole and mosapride in the treatment of gastroesophageal reflux disease.Methods:110 Patients with gastroesophageal reflux disease(GERD)from June 2016 to June 2017 were randomly divided into control group(55 cases)and observation group(55 cases).Omeprazole moxapride chaihu Shugan powder was selected in the observation group.The clinical efficacy,symptom remission time,TCM syndrome score,quality of life score and adverse reaction rate were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).comparison of symptomatic remission time between the two groups,including nausea and vomiting,belching,acid reflux and abdominal pain,was shorter in the observation group than in the control group(P<0.05).comparison of TCM syndromes such as epigastric distension pain,belching,acid regurgitation,dysphagia,loose stools,etc.After treatment,the observation group was lower than the control group(P<0.05).comparison of life quality score in somatic function,mental health,social relations,living environment,etc.After treatment,the observation group was higher than the control group(P<0.05).the total incidence of adverse reactions between the observation group and the control group was 7.27%and 3.64%respectively,and the difference between the groups was not statistically significant(P>0.05).Conclusion:The combination of Chaihu Shugan Powder and western medicine(omeprazole,mosapride)can effectively improve the clinical effect of gastroesophageal reflux disease,speed up the remission of symptoms and improve the quality of life of the patients.Moreover,the patients had less adverse reactions and were safe and reliable.