摘要
Neutrophils are heterogeneous with distinct subsets,and can switch phenotypes to exert regulatory functions on immunity.We herein demonstrate that IL-23-treated neutrophils selectively produce IL-17A,IL-17F and IL-22,and display a distinct gene expression profile in contrast to resting and lipopolysaccharide-treated neutrophils.IL-17+neutrophils are present in the colons of mice with dextran sulfate sodium-induced colitis.Adoptive transfer of IL-23-treated neutrophils significantly promotes pathogenesis in this model.IL-23 induces neutrophil polarization through STAT3-dependent RORγt and BATF pathways.Thus,IL-23-induced neutrophil polarization expresses a unique cytokine-producing profile,which may contribute to IL-23-mediated inflammatory diseases.
基金
supported by grants from the National Basic Research Program of China(2014ZX10002002-001-002,YZ
2011CB710903,YZ)
the National Natural Science Foundation of China for General and Key Programs(81530049,81130055,YZ)
the Knowledge Innovation Program of the Chinese Academy of Sciences(XDA04020202-19,YZ)
the Beijing Municipal Hospital Authority‘Yangfan Program’(ZYLX201408,XZ)
the CAS/SAFEA International Partnership Program for Creative Research Teams(YZ).
