微小RNA-29家族调控慢性肝病发生发展

MicroRNA-29 family on regulating the occurrence and development of chronic liver diseases

微小RNA-29(microRNA-29,miR-29)家族是备受研究者关注的miRNA家族之一,其主要成员包括miR-29a、miR-29b(包括尚未成熟的miR-29b-1和miR-29b-2)和miR-29c。近年研究表明,miR-29在非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)、慢性病毒性肝炎、肝硬化及肝细胞癌(hepatocellular carcinoma,HCC)等慢性肝病中异常表达。miR-29可通过靶向下游靶基因并下调其表达间接调控相关慢性肝病的发生发展,有望成为慢性肝病的早期无创鉴别诊断及预后判断的重要生物标志物和临床治疗的理想靶点。本文综述了mi R-29调控慢性肝病的研究进展。

The microRNA-29(miR-29)family is one of the miRNA families concerned by the researchers.The family members mainly include miR-29a,miR-29b(including the immature miR-29b-1 and miR-29b-2)and miR-29c.Recent studies showed that miR-29 abnormally expressed in chronic liver diseases like non-alcoholic fatty liver disease(NAFLD),chronic viral hepatitis,liver cirrhosis and hepatocellular carcinoma(HCC).miR-29 can indirectly regulate the occurrence and development of related chronic liver diseases by targeting its downstream target genes and down-regulating the expression of target genes.It is expected to be an important biomarker and an ideal clinical target for the early non-traumatic differentiation,diagnosis and prognosis judgment of chronic liver diseases.This paper reviewed the research progress of miR-29 on regulating chronic liver disease.