早孕复发性流产患者低氧诱导因子-1α、β-hCG、孕酮表达及预测价值

Expression and predictive value of HIF-1α,β-hCG,and progesterone levels of women with recurrent spontaneous abortion during the first trimester of pregnancy

目的:探究低氧诱导因子-1α(HIF-1α)、β-人绒毛膜促性腺激素(β-hCG)、孕酮(P)在早孕复发性流产(RSA)患者血清中表达及预测价值。方法:回顾性选择2018年6月-2019年6月在本院产前检查的早孕期妇女102例,根据妊娠结局分为正常妊娠组(46例)、流产组(35例)、RSA组(21例),检测3组孕妇停经6、7、8周时血清HIF-1α、β-hCG、P水平,采用pearson相关分析RSA组孕妇血清HIF-1α、β-hCG、P水平相关性,采用受试者工作特征曲线(ROC)分析3项指标对早孕RSA预测价值。结果:停经6、7、8周时血清HIF-1α水平RSA组最高、流产组次之、正常妊娠组最低,血清β-hCG和P水平RSA组最低、流产组次之、正常妊娠组最高(均P<0.05);RSA组孕妇血清HIF-1α与β-hCG呈负相关(P<0.05),血清HIF-1α、β-hCG与P均无相关性(P>0.05);血清HIF-1α、β-hCG、P联合检测对早孕RSA预测价值优于各指标单独检测(P<0.05)。结论:在早孕RSA患者血清中HIF-1α呈高表达,β-hCG、P呈低表达,血清HIF-1α、β-hCG、P联合检测对早孕RSA有较高预测价值。

Objective:To investigate the expression and predictive value of hypoxia-inducible factor-1α(HIF-1α),β-human chorionic gonadotropin(β-hCG),and progesterone(P)of women with recurrent spontaneous abortion(RSA)during the first trimester of pregnancy.Methods:102 pregnant women during the first trimester of pregnancy from June 20 to June 2019 were retrospectively selected,and were divided into three groups according to their pregnancy outcomes,which included group A(46 women with normal pregnancy),group B(35 women with abortion),and group C(21 women with RSA).The levels of serum HIF-1α,β-hCG,and P of the women during 6,7,and 8 gestational weeks in the three groups had been detected.Correlation of serum levels of HIF-1α,β-hCG,and P of women in group C was analyzed by Pearson correlation analysis.The predictive value of serum HIF-1α,β-hCG,and P levels for predicting RSA during the first trimester of pregnancy was analyzed by receiver operating characteristic(ROC)curve.Results:During 6,7,and 8 gestational weeks,the serum HIF-1αlevel of the women in group C was the highest,followed by that of the women in group B,and that of the women in group A was the lowest.During 6,7,and 8 gestational weeks,the serumβ-HCG level or P level of the women in group C was the lowest,followed by that of the women in group B,and that of the women in group A was the highest(all P<0.05).There was a negative correlation between serum HIF-1αlevel andβ-HCG level of the women in group C(P<0.05),and the serum HIF-1αlevel andβ-HCG level of the women in group C had no correlation with their serum P level(P>0.05).The predictive value of combinational detection of serum HIF-1α,β-HCG,and P levels during the first trimester of pregnancy for RSA was significant better than that of serum HIF-1αlevel,β-HCG level,or P level alone(P<0.05).Conclusion:The serum HIF-1αof the women with RSA during the first trimester of pregnancy expresses highly,while their serumβ-HCG and P levels express lowly.The combinational detection of serum HIF-1α,β-HCG,and P levels during the first trimester of pregnancy for predicting RSA has higher value.