阿加曲班联合阿司匹林治疗急性脑梗死伴心房颤动患者的效果

Effects of Agatroban combined with Aspirin in treatment of patients with acute cerebral infarction and atrial fibrillation

目的:观察阿加曲班联合阿司匹林治疗急性脑梗死伴心房颤动(房颤)患者的效果。方法:选取82例急性脑梗死伴房颤患者作为研究对象,按照随机数字表法分为对照组和研究组,各41例。对照组给予阿司匹林治疗,研究组在对照组基础上联合阿加曲班治疗,比较两组临床疗效,治疗前后血液流变学指标[血浆黏度、红细胞沉降率、血小板聚集率]水平、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数评分和不良反应发生率。结果:研究组治疗总有效率为90.24%,高于对照组的73.17%,差异有统计学意义(P<0.05);治疗后,研究组血浆黏度、红细胞沉降率和血小板聚集率及NIHSS评分均低于对照组,Barthel指数评分高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿加曲班联合阿司匹林治疗急性脑梗死伴房颤患者能够促进血液流动,改善神经功能,提高日常生活活动能力,效果优于单用阿司匹林,且较为安全。

Objective: To investigate effects of Agatroban combined with Aspirin in treatment of patients with acute cerebral infarction and atrial fibrillation. Methods: 82 patients with acute cerebral infarction and atrial fibrillation were selected and divided into control group and study group according to the random number table method, 41 cases in each group. The control group was treated with Aspirin, while the study group was treated with Argatroban on the basis of that of the control group. The clinical efficacy, the levels of hemorheology indexes [plasma viscosity, erythrocyte sedimentation rate, platelet aggregation rate] before and after the treatment, the National Institutes of Health Stroke scale(NIHSS) score, the Barthel index score, and the incidence of adverse reactions were compared between the two groups. Results: The total effective rate of treatment in the study group was 90.24%, which was higher than 73.17% in the control group, and the difference was statistically significant(P<0.05). After the treatment, the plasma viscosity, the erythrocyte sedimentation rate, the platelet aggregation rate and the NIHSS score of the study group were lower than those of the control group;the Barthel index score was higher than that of the control group;and the differences were statistically significant(P<0.05). However, there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusions: Agatroban combined with Aspirin in the treatment of the patients with acute cerebral infarction and atrial fibrillation can promote the blood flow, improve the nerve function, and improve the activities of daily living with good safety Moreover, it is superior to single Aspirin.