右美托咪定联合舒芬太尼对重症急性胰腺炎患者镇痛效果的影响

Effect of dexmedetomidine combined with sufentanil on analgesia in patients with severe acute pancreatitis

目的探讨右美托咪定联合舒芬太尼用药对重症急性胰腺炎(SAP)患者镇静镇痛治疗的临床效果。方法选取2018年1月~2020年1月克拉玛依市中心医院收治的46例SAP患者作为研究对象,采用随机数表法均分为对照组和观察组,每组23例。对照组患者使用舒芬太尼镇痛,观察组患者联合使用右美托咪定和舒芬太尼镇痛镇静。观察并比较两组患者用药后的镇痛镇静效果及不良反应率。结果观察组患者的镇静达标时间、给药后苏醒时间、重症监护室(ICU)住院时间等指标均短于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率低于对照组患者,差异有统计学意义(P<0.05)。结论SAP患者联合使用舒芬太尼和右美托咪定镇静镇痛效果优秀,安全可靠,可临床应用。

Objective To explore the clinical effect of dexmedetomidine combined with sufentanil on sedation and analgesia in patients with severe pancreatitis(SAP).Methods A total of 46 patients with SAP in our hospital from January 2018 to January 2020 were selected and randomly divided into control group(23 cases)and observation group(23 cases).The control group were given sufentanil for analgesia,while the observation group were given dexmedetomidine and sufentanil for analgesia and sedation.The analgesic and sedative effects and adverse reaction rates of the two groups were observed and compared.Results The sedation standard time,recovery time after administration,ICU hospitalization time and other indicators of the observation group were shorter than those of the control group,with statistical significance(P<0.05).The incidence of adverse reactions in the observation group was lower than the control group,with statistical significance(P<0.05).Conclusion Combined use of sufentanil and dexmedetomidine in SAP patients has excellent sedative and analgesic effects,which is safe and reliable,and can be used clinically.