血清HBP、PTX3表达水平与重症肺炎患儿病情严重程度及预后的相关性

Correlation Between Serum HBP and PTX3 Expression Levels and Severity and Prognosis of Children with Severe Pneumonia

目的探究血清肝素结合蛋白(HBP)、正五聚蛋白3(PTX3)表达水平与重症肺炎患儿病情严重程度及预后的相关性。方法选取2018年3月至2020年7月我院收治的113例肺炎患儿作为研究对象,依据危重病例评分将80~100分患儿设置为普通肺炎组(58例),80分以下设置为重症肺炎组(53例),其中死亡9例(死亡组),存活44例(存活组)。同期选取正常体检儿童42例作为对照组。采用酶联免疫吸附法测定各组血清HBP、PTX3水平。对比各组血清HBP、PTX3以及相关炎性因子水平,采用Person分析血清HBP、PTX3与炎性因子的相关性,同时采用接收者操作特征曲线(ROC)分析上述各临床指标对重症肺炎患儿预后的统计学效力。结果重症肺炎组及普通肺炎组的PCT、CRP、WBC、NEC、HBP及PTX3均明显高于对照组(P<0.05),且重症肺炎组的PCT、CRP、HBP及PTX3水平对比普通肺炎组有明显升高(P<0.05);死亡组患儿PCT、CRP、HBP及PTX3水平均明显高于存活组(P<0.05);Pearson相关性分析中,血清HBP、PTX3水平与CRP、PCT呈正相关(P>0.05);ROC曲线显示,HBP、PTX3预测重症肺炎患儿预后的AUC分别为0.794、0.789,明显高于PCT、CRP单个临床指标。结论血清HBP、PTX3表达水平与重症肺炎患儿病情严重程度及预后有密切相关性,可作为重症肺炎发生和重症肺炎患儿死亡的早期预测指标。

Objective To explore the correlation between the expression levels of serum heparin binding protein(HBP)and pentraxin 3(PTX3)and the severity and prognosis of children with severe pneumonia.Methods A total of 113 children with pneumonia admitted to our hospital from March 2018 to July 2020 were selected as the research objects.According to the critical case score,children with a score of 80-100 were assigned to the common pneumonia group(58 cases),and those with a score of less than 80 were set as the severe pneumonia group(53 cases),among which 9 cases died(death group)and 44 cases survived(survival group).At the same time,42 children with normal physical examination were selected as the control group..Enzyme-linked immunosorbent assay was used to determine serum HBP and PTX3 levels in each group.Comparison of the levels of serum HBP,PTX3 and related inflammatory factors in each group was carried out.Paerson correlation analysis was used to analyze the correlation between serum HBP,PTX3 and inflammatory factors,and receiver operating characteristic curve(ROC)was employed to analyze the prognosis of the above clinical indicators for children with severe pneumonia Statistical power.Results PCT,CRP,WBC,NEC,HBP,and PTX3 in the severe pneumonia group and the common pneumonia group were significantly higher than those in the control group(P<0.05),and the levels of PCT,CRP,HBP and PTX3 in the severe pneumonia group were significantly higher than those in the common pneumonia group(P<0.05);the levels of PCT,CRP,HBP and PTX3 in the death group were significantly higher than those in the survival group(P<0.05);in the Pearson correlation analysis,serum HBP and PTX3 levels were positively correlated with CRP and PCT(P>0.05);ROC curve showed that the AUC of HBP and PTX3 predicting the prognosis of children with severe pneumonia were 0.794 and 0.789,respectively,which were significantly higher than the single clinical indicators of PCT and CRP.Conclusion Serum HBP and PTX3 expression levels are closely related to the severity and prognosis of children with severe pneumonia,and can be used as early predictors of the occurrence of severe pneumonia and the death of children with severe pneumonia.