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RAD51D在卵巢癌中的研究进展

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摘要 卵巢癌(ovarian cancer,OC)是女性第七位常见的恶性肿瘤,同时在癌症死亡原因中排名第八。最新统计显示,2020年美国OC的死亡病例数约14000,其死亡率居妇科恶性肿瘤之首,严重威胁女性生命健康。OC起病隐匿,发现时多属晚期以及预后较差是其公认的特点。目前针对OC的治疗方式以手术切除病灶和铂类药物化疗为主,尽管手术方法与化疗方案不断改进,仍有部分患者会产生耐药、复发进而死亡,导致OC的5年生存率低于45%[1]。
出处 《四川医学》 CAS 2021年第6期629-632,共4页 Sichuan Medical Journal
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  • 1王玉林,赵荣宇,张丽芝,关宏伟.BRCA1和BRCA2在乳腺疾病中的表达和意义[J].医师进修杂志(外科版),2005,28(5):13-15. 被引量:11
  • 2Xing D, Tan W, Lin D. Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review). Oncol Rep, 2003; 10(5): 1615-1623.
  • 3Hiyama T, Yoshihara M, Tanaka S, et al . Genetic polymorphisms and esophageal cancer risk. Int J Cancer, 2007 ; 121(8):1643-1658.
  • 4Goode EL, Ulrich CM, Potter JD. Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev,2002;11(12) :1513-1530.
  • 5Qiao GB, Wu YL, Yang XN, et al . High-level expression of Rad51 is an independent prognostic marker of survival in non?small-cell lung cancer patients. Br J Cancer, 2005; 93 (1) : 137- 143.
  • 6Rollinson S, Smith AG, Allan JM, et al . RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Leuk Res,2007;31(2) :169-174.
  • 7Poplawski T, Arabski M, Kozirowska D, et al . DNA damage and repair in gastric cancer--a correlation with the hOGG1 and RAD51 genes polymorphisms. Mutat Res, 2006; 601 (1-2): 83-91.
  • 8Richardson C, Stark JM, ommundsen M, et al . Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability. Oncogene, 2004; 23 (2) : 546- 553.
  • 9Bhatia D, Gerbing RB, Alonzo TA, et al . DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Ontology Group. Leukemia,2008;22(2) :265-272.
  • 10Sung, P, Klein H. Mechanism of homologous recombination: mediators and helicases take on regulatory functions. Nat Rev Mol Cell Biol,2006;7(10): 739-750.

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