肝脏因子FABP1与血脂异常的相关性分析

Analysis of the correlation between hepatokine FABP1 and dyslipidemia

目的探讨血脂异常患者肝脏因子脂肪酸结合蛋白1(FABP1)的变化及其与血脂异常的相关性。方法回顾性分析2020年3-10月在西部战区总医院心血管内科住院的122例患者的临床资料,根据血脂水平及纳入排除标准,确定血脂异常者72例,血脂正常者50例。收集所有研究对象的一般资料,包括性别、年龄、身高、体重、烟酒嗜好等。检测血脂、血糖、血管生成素样蛋白(ANGPTL)3、ANGPTL4、ANGPTL6、FABP1。采用倾向性得分匹配(PSM)法均衡两组基线资料中存在的混杂因素,比较两组FABP1的变化,并采用二元logistic回归分析血脂异常的危险因素,多元线性回归分析FABP1与各血脂成分的相关性。结果经PSM法均衡混杂因素后,两组年龄、性别、烟酒嗜好、体重指数(BMI)、血糖差异无统计学意义(P>0.05);血脂异常组的高密度脂蛋白胆固醇(HDL-C)水平明显低于血脂正常组(P<0.05),总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)水平明显高于血脂正常组(P<0.05)。血脂异常组的血清FABP1水平明显高于于血脂正常组(P<0.05),而血清ANGPTL3、ANGPTL4、ANGPTL6水平两组间差异无统计学意义(P>0.05)。二元logistic回归分析结果显示,FABP1为血脂异常的独立危险因素(OR=1.011,P<0.05);多元线性回归分析结果显示,TG与FABP1呈显著正相关(β=0.291,P<0.05),TC+LDL-C、血糖与FABP1呈显著负相关(β=–0.443、–0.268,P<0.05)。结论FABP1与血脂异常尤其TG的代谢异常密切相关。

Objective To investigate the alterations of hepatokines fatty acid binding protein 1(FABP1)in patients with dyslipidemia and their correlation with dyslipidemia.Methods The clinical data of 122 patients hospitalized in the Department of Cardiovascular Medicine of General Hospital of Western Theater Command during March to October 2020 were analyzed retrospectively.According to the blood lipids level and the criteria of inclusion and exclusion,72 patients with abnormal blood lipids level(abnormal blood lipid group)and 50 patients with normal blood lipids level(normal blood lipid group)were identified.General information of all subjects was collected,including gender,age,height,weight,smoking and drinking habits,etc.Blood lipid,blood glucose,angiopoietin like protein(ANGPTL)3,ANGPTL4,ANGPTL6,FABP1 were detected.Propensity score matching(PSM)method was used to balance the confounding factors in the baseline data for comparing the alterations of hepatokines between the two groups.Binary logistic regression was used to analyze the risk factors of dyslipidemia,and multiple linear regression was used to analyze the correlation between FABP1 and blood lipid components.Results After balancing confounding factors by PSM method,no statistically significant difference existed in age,gender,tobacco and alcohol addiction,BMI and blood glucose between the two groups(P>0.05).The level of HDL-C was significantly lower,and the levels of TC,LDL-C and TG were significantly higher in abnormal blood lipid group than in normal blood lipid group(P<0.05).FABP1 level was significantly higher in abnormal blood lipid group than that in normal blood lipid group(P<0.05),while no statistical difference existed between the two groups in the serum levels of ANGPTL3,ANGPTL4 and ANGPTL6(P>0.05).Binary logistic regression analysis showed that FABP1 was an independent risk factor for dyslipidemia(OR=1.011,P<0.05).Multiple linear regression analysis showed that a significant positive correlation existed between TG and FABP1(β=0.291,P<0.05),and a significant negative correlation existed between TC+LDL-C and FABP1,as well as blood glucose and FABP1(β=–0.443 andβ=–0.268,P<0.05).Conclusion FABP1 is closely related to dyslipidemia,especially to the abnormal metabolism of triglyceride.