高原肺水肿防治研究进展

Prevention and treatment of acute high pulmonary edema:research progress

高原肺水肿(HAPE)是由高原低压低氧引起的一种高原特发疾病,严重威胁着急进高原健康人群的生活质量及作业能力,严重时甚至可危及生命。HAPE的救治仍存在诸多问题,如发生肺水肿时利尿剂的使用、有效血容量的补充、高压氧舱的应用时机、机械通气的参数设置等。该文从HAPE分型、发病机制、临床表现、预防及治疗等方面进行综述。

High-altitude pulmonary edema(HAPE)is a plateau-specific disease caused by low-pressure hypoxia in the plateau,which seriously threatens the quality of life and operational ability and,in severe cases,life in healthy people who have sharply advanced to the plateau.Although the treatment of the disease has been significantly improved,there are still some existing issues in the treatment.For instance,how to balance diuretic use,the effective blood volume supplementation,the timing of hyperbaric oxygen chamber application,and mechanical ventilation parameter settings in pulmonary edema,etc.This review reflects on the typology,pathogenesis,clinical manifestations,prevention and treatment considerations in plateau pulmonary edema.