连续性血液净化治疗多器官功能障碍对机体免疫功能的影响评价

Evaluation of the Effect of Continuous Blood Purification Treatment of Multiple Organ Dysfunction on the Body's Immune Function

目的分析连续性血液净化治疗多器官功能障碍对机体免疫功能的影响。方法2017年5月—2020年5月纳入58例多器官功能障碍患者,以电脑随机分组为对照组29例、观察组29例,对应实施常规治疗、连续性血液净化治疗,分析对患者机体免疫功能的影响。结果治疗后,观察组免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白G(immunoglobulin G,IgG)及CD4^(+)水平为(1.97±0.26)g/L、(1.50±0.18)g/L、(14.78±1.22)g/L、(47.88±9.04)%,较对照组高,CD8^(+)水平(20.11±2.30)%,较对照组低,差异有统计学意义(t=4.480、4.600、12.550、3.020、8.220,P<0.05)。治疗3、5、7 d后,观察组急性生理学和慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分(16.00±2.04)分、(13.23±1.14)分、(8.15±1.36)分,低于对照组,差异有统计学意义(t=6.500、10.220、5.440,P<0.05)。治疗后,观察组C反应蛋白(C-reactionprotein,CRP)、血清淀粉样蛋白A(serum amyloid A protein,SAA)水平(110.00±20.75)mg/L、(240.11±30.35)mg/L,低于对照组,单核细胞数量(0.94±0.16)×10^(9)/L,高于对照组,差异有统计学意义(t=6.150、4.860、5.820,P<0.05)。观察组治愈率(89.66%)高于对照组,差异有统计学意义(χ^(2)=4.860,P<0.05)。结论多器官功能障碍患者实施连续性血液净化治疗可显著减轻机体炎性反应,促进免疫功能恢复。

Objective To analyze the effect of continuous blood purification treatment of multiple organ dysfunction on the immune function of the body.Methods From May 2017 to May 2020,58 patients with multiple organ dysfunction were randomly divided into groups,29 cases in the control group and 29 cases in the observation group,corresponding to conventional treatment and continuous blood purification treatment,and analysis of the patients of the influence of the body's immune function.Results After treatment,the levels of immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)and CD4^(+)in the observation group were(1.97±0.26)g/L,(1.50±0.18)g/L,(14.78±1.22)g/L,and(47.88±9.04)%,higher than the control group,with a CD8^(+)level(20.11±2.30)%,which was lower than the control group,which was statistically significant(t=4.480,4.600,12.550,3.020,8.220,P<0.05).After 3,5,and 7 d of treatment,the acute physiology and chronic health evaluationⅡ(APACHEⅡ)scores of the observation group were(16.00±2.04)points,(13.23±1.14)points,(8.15±1.36)points,which were lower than those of the control group,which were statistically significant(t=6.500,10.220,5.440,P<0.05).After treatment,the levels of C-reactionprotein(CRP)and serum amyloid A protein(SAA)in the observation group were(110.00±20.75)mg/L and(240.11±30.35)mg/L,which were lower than those of the control group,and the number of monocytes was(0.94±0.16)×10^(9)/L,which was higher than that of the control group.There was statistical significance(t=6.150,4.860,5.820,P<0.05).The cure rate of the observation group(89.66%)was higher than that of the control group,which was statistically significant(χ^(2)=4.860,P<0.05).Conclusion Continuous blood purification treatment in patients with multiple organ dysfunction can significantly reduce the body's inflammatory response and promote the recovery of immune function.