早发冠心病临床危险因素分析及其与预后的相关性探讨

Analysis of Clinical Risk Factors of Premature Coronary Heart Disease and Its Correlation with Prognosis

目的观察分析早发冠心病临床危险因素分析及其与预后的相关性。方法选取该院在2019年1—12月收治的126例早发冠心病患者一般资料作为研究组,再选取同期该院收治的126例非早发冠心病患者一般资料作为对照组。分析两组研究对象的血液指标(总胆固醇、血红蛋白、纤维蛋白原以及总胆红素等)、不良事件发生率。结果研究组总胆固醇、血红蛋白、纤维蛋白原以及总胆红素等水平分别为(5.47±1.30)mmol/L、(140.21±12.95)g/L、(4.48±1.33)g/L、(13.90±8.05)μmol/L,对照组总胆固醇、血红蛋白、纤维蛋白原以及总胆红素等水平分别为(4.22±1.11)mmol/L、(130.22±16.15)g/L、(3.22±1.25)g/L、(10.08±7.10)μmol/L,研究组总胆固醇、血红蛋白、纤维蛋白原以及总胆红素等水平明显高于对照组,差异有统计学意义(t=8.208、5.417、7.749、3.995,P<0.05);研究组患者死亡(15.9%)、再次血运重建(10.3%)的发生率与对照组(16.7%、10.3%)比较,差异无统计学意义(χ^(2)=0.029、0.000,P>0.05);单因素分析早发冠心病患者的临床危险因素有高血压、吸烟史、冠心病家族史(P<0.05);多因素分析影响早发冠心病患者的预后因素有总胆固醇、吸烟史、冠心病家族史、血红蛋白以及高血压等(P<0.05)。结论早发冠心病临床危险因素比较多,临床需加强针对性干预,以期提高临床预后效果。

Objective To observe and analyze the clinical risk factors of early-onset coronary heart disease and its correlation with prognosis.Methods The general data of 126 patients with premature coronary heart disease collected in this hospital from January to December 2019 were selected as the study group,and the general data of 126 patients with non-premature coronary heart disease collected in the hospital during the same period were selected as the control group.The blood indicators(total cholesterol,hemoglobin,fibrinogen,total bilirubin,etc.)and adverse event rate of the two groups of subjects were analyzed.Results The levels of total cholesterol,hemoglobin,fibrinogen and total bilirubin in the study group were(5.47±1.30)mmol/L,(140.21±12.95)g/L,(4.48±1.33)g/L,(13.90±8.05)μmol/L,the levels of total cholesterol,hemoglobin,fibrinogen and total bilirubin in the control group were(4.22±1.11)mmol/L,(130.22±16.15)g/L,(3.22±1.25)g/L,(10.08±7.10)μmol/L,the levels of total cholesterol,hemoglobin,fibrinogen and total bilirubin in the study group were significantly higher than those in the control group,and the difference was statistically significant(t=8.208,5.417,7.749,3.995,P<0.05);compared with the control group(16.7%,10.3%)in the incidence of death(15.9%)and revascularization(10.3%)in the study group,the difference was not statistically significant(χ^(2)=0.029,0.000,P>0.05);univariate analysis of clinical risk factors for patients with early-onset coronary heart disease:hypertension,smoking history,family history of coronary heart disease(P<0.05);multivariate analysis influence of prognostic factors of patients with early-onset coronary heart disease included:total cholesterol,smoking history,family history of coronary heart disease,hemoglobin,and hypertension.Conclusion There are many clinical risk factors for early-onset coronary heart disease,and clinically targeted interventions are needed to improve the clinical prognosis.