氨磺必利与利培酮对精神分裂症的治疗效果及不良反应情况对比研究

A Comparative Study on the Therapeutic Effects and Adverse Reactions of Amisulpride and Risperidone on Schizophrenia

目的研究并对比氨磺必利与利培酮在精神分裂症中的治疗效果以及不良反应发生情况。方法选取2018年3月—2020年3月期间在该院接受治疗的68例精神分裂症患者进行研究,按照入院治疗顺序进行分组,每组34例。对照组接受利培酮治疗,研究组接受氨磺必利治疗。对比两组患者治疗效果及不良反应。结果研究组治疗有效率为94.12%,明显高于对照组67.65%,差异有统计学意义(χ^(2)=5.084,P<0.05);研究组不良反应发生率为为8.82%,对照组不良反应发生率为50.00%,研究组低于对照组,差异有统计学意义(χ^(2)=7.625,P<0.05)。结论相较利培酮而言,氨磺必利在精神分裂症患者中的应用效果更好,不仅可以有效提高治疗总有效率,同时还可以降低血压异常等不良反应发生的概率,值得在临床上大力推广。

Objective To study and compare the effects of amisulpride and risperidone in the treatment of schizophrenia and the occurrence of adverse reactions.Methods The 68 patients with schizophrenia who were treated in the hospital from March 2018 to March 2020 were selected for the study.They were grouped according to the order of admission and treatment,with 34 cases in each group.The control group received risperidone treatment,and the study group received amisulpride treatment.The treatment effects and adverse reactions of the two groups of patients were compared.Results The treatment effective rate of the study group was 94.12%,which was significantly higher than that of the control group 67.65%,the difference was statistically significant(χ^(2)=5.084,P<0.05);the adverse reaction rate of the study group was 8.82%,and the adverse reaction rate of the control group was 50.00%,the study group was lower than the control group,the difference was statistically significant(χ^(2)=7.625,P<0.05).Conclusion Compared with risperidone,amisulpride has a better application effect in patients with schizophrenia.It can not only effectively increase the total effective rate of treatment,but also reduce the probability of adverse reactions such as abnormal blood pressure.It is worthwhile vigorously promotion clinically.