血清非高密度脂蛋白胆固醇与脑梗死急性期神经功能损害的相关性分析

Correlation analysis between serum non-high density lipoprotein-cholesterol and neurological impairment in acute phase of cerebral infarction

目的探讨血清非高密度脂蛋白胆固醇(non-HDL-C)与脑梗死急性期神经功能损害的相关性。方法选取2018年4月~2020年5月肇庆市中医院神经内科收治的132例脑梗死患者作为研究对象,以66例同期健康体检者作为对照组,分析两组血脂水平的差异;根据non-HDL-C水平将脑梗死患者分为正常(n=42)与升高(n=90)两个级别,比较不同non-HDL-C水平患者的临床资料、血脂水平、神经功能评分,分析non-HDL-C水平与其他血脂指标、神经功能指标的相关性。结果脑梗死组的HDL-C水平低于对照组,non-HDL-C、低密度脂蛋白胆固醇(LDL-C)、胆固醇(TC)、三酰甘油(TG)水平均高于对照组,差异有统计学意义(P<0.05)。non-HDL-C升高患者中男性比例高于non-HDL-C正常患者,差异有统计学意义(P<0.05);non-HDL-C升高患者的TC、non-HDL-C、LDL-C、TG水平及美国国立卫生研究院卒中量表(NIHSS)评分均高于non-HDL-C正常患者,HDL-C水平与斯堪的纳维亚神经功能缺损量表(SSS)评分均低于non-HDL-C正常患者,差异有统计学意义(P<0.05)。non-HDL-C与TC、LDL-C、TG、NIHSS评分呈正相关,而与HDL-C、SSS评分呈负相关(P<0.05)。结论血清non-HDL-C与脑梗死急性期神经功能损害呈现显著正相关关系,可作为评估脑梗死神经功能损害的标志。

Objective To investigate the correlation between serum non-high density lipoprotein-cholesterol(non-HDL-C)and neurological impairment in acute phase of cerebral infarction.Methods A total of 132 patients with cerebral infarction admitted to the Department of Neurology,Zhaoqing Hospital of Traditional Chinese Medicine from April 2018 to May 2020 were selected as the research objects,and 66 healthy people during the same period were selected as the control group.The differences of blood lipid levels between the two groups were analyzed.According to the level of non-HDL-C,the patients with cerebral infarction were divided into normal non-HDL-C group and elevated non-HDL-C group.The clinical data,blood lipid levels and neurological function scores of patients with different levels of non-HDL-C were compared.The correlation between non-LDL-C level and other blood lipid indexes,neurological function indexes was analyzed.Results The level of HDL-C in the cerebral infarction group was lower than that in the control group,and the levels of non-HDL-C,low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),and triacylglycerol(TG)were higher than those in the control group,the differences were statistically significant(P<0.05).The proportion of male in patients with elevated non-HDL-C was higher than that in patients with normal non-HDL-C,the difference was statistically significant(P<0.05).The levels TC,non-HDL-C,LDL-C,TG and National Institutes of Health stroke scale(NIHSS)score in patients with elevated non-HDL-C were higher than those in patients with normal non-HDL-C,while HDL-C level and Scandinavian stroke scale(SSS)score were lower than those in patients with normal non-HDL-C,with statistically significant differences(P<0.05).The non-HDL-C was positively correlated with TC,LDL-C,TG and NIHSS score,but negatively correlated with HDL-C and SSS score(P<0.05).Conclusion Serum non-HDL-C has a significant positive correlation with neurological impairment in acute stage of cerebral infarction,which can be used as a marker for evaluating neurological impairment in cerebral infarction.