硫酸镁注射液联合硝苯地平治疗妊娠高血压综合征的效果

Additive effect of Magnesium Sulfate combined with Nifedipine for the treatment of pregnancy-induced hypertension syndrome

目的探析硫酸镁注射液联合硝苯地平治疗妊娠高血压综合征的效果。方法选取广东省珠海市妇幼保健院2015年1月~2020年1月收治的60例妊娠高血压综合征患者为研究对象,按照随机数字表法分为观察组与对照组各30例,对照组单纯应用硫酸镁注射液治疗,观察组给予硫酸镁注射液联合硝苯地平治疗方案,比较治疗前后两组患者的血压指标、药物治疗有效率、药物不良发生率及生活质量。结果观察组治疗后血压低于对照组,差异有统计学意义(P<0.05);观察组患者药物治疗的有效率高于对照组,差异有统计学意义(P<0.05);观察组的不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05);观察组的生活质量各维度所得分数均高于对照组,差异有统计学意义(P<0.05)。结论硫酸镁注射液联合硝苯地平能够有效调整妊娠高血压综合征患者的血压指标,提高疗效,产后安全性有保证,提高产妇围生期的生活质量,值得临床推广。

Objective To explore the effect of magnesium sulfate combined with Nifedipine in the treatment of hypertension in pregnancy.Methods A total of 60 patients with pregnancy-induced hypertension admitted to Guangdong Province Zhuhai Maternity and Child Health Hospital from January 2015 to January 2020 were selected as the research objects,and they were divided into an observation group and a control group by random number table method,each had 30 cases,the control group was treated with Magnesium Sulfate Injection alone,and the observation group was treated with Magnesium Sulfate Injection combined with Nifedipine.The blood pressure indicators,effective rate of drug treatment,adverse drug incidence and quality of life were compared between the two groups before and after treatment.Results The blood pressure index after treatment in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05);the effective rate of drug treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05);the incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,which was statistically significant(P<0.05);the scores of all dimensions of the quality of life in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion Magnesium sulfate injection combined with nifedipine can effectively adjust the blood pressure indicators of patients with pregnancy-induced hypertension,improve the efficacy,ensure postpartum safety,and improve the quality of life of women in the perinatal period.It is worthy of clinical promotion.