2-氨基甲基-3-氯-5-三氟甲基吡啶的制备方法

Preparation of 2-(Aminomethyl)-3-chloro-5-(trifluoromethyl)pyridinehydrochloride

本发明以2-氰基-3-氯-5-三氟甲基吡啶为原料,在溶剂醋酸中经过低压加氢还原一步得到2-氨基甲基-3-氯-5-三氟甲基吡啶的盐酸盐。本发明方法优点在于设备要求低、收率高、易工业化生产等优点。

2-(aminomethyl)-3-chloro-5-(trifluoromethyl)pyridine hydrochloride was synthesised by 2-cyano-3-chloro-5-(trifluoromethyl)-pyridine with acetic acid,which was in low pressure hydrogenation reduction in one step.The method has the advantages of low equipment requirements,high yield,easy to realize the industrialization.